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In the present prospective, randomized, double-blind study with 144 smokers, 23.7% of the patients receiving placebo stopped smoking, compared to 55.9% of the patients receiving nortriptyline (p < 0.001). Individuals were considered to have stopped smoking if they claimed total abstinence from cigarette smoking for at least 1 week. Our results were comparable to those montesino and cigar of another randomized study by Hurt et al, (16) which included 615 patients who had been treated with bupropion. In the sixth week of the study, the abstinence rate was 19% for the group receiving placebo and 44.2% for the group receiving bupropion (p < 0.001).Prochazka et al (18) in a randomized, double blind, placebo-controlled study with 214 patients, evaluated the effects of nortriptyline montesino on the rate of ceasing to smoke. The success rate for the group that received the active drug was 50%, compared to cigar 32% for the group receiving placebo. Only 12% of the patients had a history of depression, compared to 48% in the population of our study. Despite the difference between the two studies in the methodologies used to obtain this information (in our study, the report on montesino psychiatric treatment for the diagnosis of depression was considered as previous cigar and montesino history of depression, while in the study by Prochazka et al, (18) a structured questionnaire was applied [ie, the diagnostic cigar interview schedule]), the difference between the two populations could montesino explain the different in the rate of success in ceasing to smoke.

For years, tobacco companies consistently denied that they were marketing cigarettes to minors, and insisted that their advertising was exclusively directed to maintain or increase market share among adults.(34) On March 20, 1997, however, the solidarity among the companies changed. In an unprecedented concession to settle lawsuits with twenty-two state attorneys general,(35) the industry''s smallest tobacco company, the Liggett Group, admitted that the industry markets its products to underage youths.(36) In addition, the company agreed to turn over thousands of internal cigar documents, waiving its right to claim confidentiality for papers that ordinarily montesino would be covered cigar by the attorney-client privilege.(37) Some of those documents involve joint discussions between attorneys for Liggett and other tobacco companies and could support allegations montesino that the companies deliberately hid research showing that cigarettes are addictive.(38) Although the impact this development will have on the tobacco industry remains to be seen, it nonetheless provides the FDA with powerful ammunition to fight lawsuits challenging cigar the montesino regulations.(39) Among the strongest evidence supporting the FDA''s position are recently released cigar internal memos that show the tobacco industry developed a "direct advertising appeal to younger smokers."(40) Several memos, for example, show that R.J. Reynolds, the nation''s number two cigarette maker, targeted teenagers as young as thirteen and even montesino created a brand specifically aimed at boys.(41) Other documents illustrate cigar that R.J. Reynolds''s popular and highly controversial Joe Camel campaign targeted teens despite the company''s repeated denials.(42) In addition, as recently as 1988, the company planned to saturate areas where teenagers gathered, such as fast-food restaurants, video game arcades and outdoor basketball courts, with billboard and poster advertisements.(43) All of these documents directly contradict R.J. Reynolds Chairman James Johnson''s 1994 statement to Congress that, "We do not market to children and will not."(44) Furthermore, several memos implicate a similar marketing strategy by R.J. Reynolds''s chief competitor, Philip Morris, which is also the nation''s largest tobacco company.(45) Although both companies continue to deny that they market to children, these memos clearly indicate awareness of their market share among teenagers, as well as the industry''s willingness to market cigarettes to children through direct advertising.(46)