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In the present prospective, randomized, double-blind study with 144 smokers, 23.7% of the patients laflordominicanacigar receiving placebo stopped smoking, compared to 55.9% of the patients receiving nortriptyline (p < 0.001). laflordominicanacigar Individuals were considered to have stopped smoking if they claimed total abstinence from cigarette smoking for at least 1 week. Our results were comparable to those of another randomized study by Hurt et al, (16) which included 615 patients who had been treated with bupropion. In the sixth week of the study, the abstinence rate was 19% for the group receiving placebo and 44.2% for the group receiving bupropion (p < 0.001).Prochazka et al (18) in a randomized, double blind, placebo-controlled study with 214 patients, evaluated the effects of nortriptyline on the rate of ceasing to smoke. The success rate for the group that received the active drug was 50%, compared to 32% for the group receiving placebo. Only 12% of the patients had a history of depression, compared to 48% in the population of our study. Despite the difference between the two studies laflordominicanacigar in the methodologies used to obtain this information (in our study, the report on psychiatric laflordominicanacigar treatment for the diagnosis of depression was considered as previous history of depression, while in the study by Prochazka et al, (18) a structured questionnaire was applied [ie, the diagnostic interview schedule]), laflordominicanacigar the difference between the two populations could explain the different in the rate of success in ceasing to smoke.